In dogs, the canine distemper virus (CDV) impacts the brain, spinal cord, respiratory systems, and gastrointestinal and respiratory tracts. High fever, eye irritation, discharge, labored breathing and coughing, vomiting and diarrhea, loss of appetite and fatigue, and hardening of the nose and footpads are a few of the symptoms that are frequently present. The viral infection can cause secondary bacterial infections and potentially severe neurological effects.